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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A hospital's P & T Committee is considering whether a particular drug should be considered for therapeutic substitution. The pharmacotherapy specialist considers the acquisition cost of each medication and recommends using the drug with the lower cost. Which of the following types of analysis has the pharmacotherapy specialist used?

A) Cost-effectiveness
B) Cost-minimization
C) Cost-utility
D) Cost-benefit

2. A physician suspects that a patient's symptoms are related to abrupt discontinuation of a certain drug and asks the pharmacotherapy specialist about common reactions in this type of situation.
A literature search produces one case report of a discontinuation syndrome involving the drug.
What is the most appropriate action to take with regard to the current suspected adverse event?

A) Report the event to the FDA MedWatch program.
B) Write and submit a case report detailing the event.
C) Complete a manufacturer's adverse event report.
D) Report the event to the P & T Committee.

3. Initial efficacy data on an experimental drug in the United States are usually collected in:

A) Phase trials.
B) Phase trials.
C) Phase III trials.
D) Phase IV trials.

4. A 75 year old patient with a BP of 70/40 mm HR and HR of 35 bpm after CPR should FIRST receive which of the following intravenous medications?

A) Atropine
B) Dopamine
C) Epinephrine
D) Isoproterenol

5. A 70-year-old 45-kg patient is admitted to the ICU with a diagnosis of digoxin intoxication. The patient complains of nausea, blurred vision, and fatigue that have been present for 3 days. A cardiac monitor reveals a HR of 42 bpm, an irregular rhythm, and a type second-degree heart block. Current medications include digoxin 0.25 mg and furosemide 40mg for heart failure, both taken daily at 0800. The patient remains adherent to all medications despite nausea, including today's doses. Blood is drawn at 1200 with the following results:
* Potassium: 6.0 mEq/L
* Creatinine: 2.3 mg/dL
* Digoxin: 1.7 ng/mL
Which of the following most appropriately describes the patient's digoxin concentration?

A) A pre-distribution digoxin concentration, which may be misinterpreted
B) A concentration within the desirable range
C) A post-distribution digoxin concentration, which indicates significant toxicity
D) Reflects the effect of furosemide on the renal excretion of digoxin

Solutions: